Cell-Dependent Signaling Profiles of GPCR Ligands in Recombinant and Native Cells
Thursday, October 09, 2008, 9:00 AM Eastern Time (ET)
GPCRs represent an important class of molecular targets for development of therapeutic agents. Emerging evidence suggests, however, that compound efficacy does not only depend on the ligand/receptor couple but also on the nature of available signaling pathways engaged by the individual receptor in each cell line. This talk will give selected examples showing effector-dependent efficacy of molecules affecting GPCR-behavior and address the potential usefulness of label free technologies in analyzing receptor signaling in recombinant and native cells.
Speaker: Evi Kostenis, Ph.D.
Evi Kostenis, Ph.D. has been appointed to a Full Professor Position in the University of Bonn in 2006 where she founded a new department in the Institute for Pharmaceutical Biology (Department of Molecular-, Cellular-, and Pharmacobiology). Her group is interested in exploring the roles of G protein coupled receptors in health and disease paradigms, in development of novel assay technologies for membrane proteins such as neurotransmitter transporters and GPCRs, and in generation of specific signal transduction inhibitors which target intracellular proteins activated upon GPCR stimulation.
She was previously employed in biotech and pharmaceutical companies. During her time at Aventis Pharma (now Sanofi-Aventis), she was exposed to both assay development and drug discovery of GPCR projects from target identification to lead optimization
We hope you will join us for this exclusive event.