Use of Label-Free Optical Biosensors to Detect Ion Channel Interactions
Tuesday, July 07, 2009, 10:00 AM Eastern Time (ET)

Based on optical biosensor technology, the label-free Corning EpicŪ System is sensitive enough to detect ion channel activity by monitoring the dynamic mass redistribution of intracellular proteins. Traditional assays examining the interaction between channels and regulatory cytoplasmic proteins generally provide no information on the time course of interactions in living cells. This presentation will describe the use of the Epic System to probe the interactions of Slack sodium-activated potassium channels with potassium channel openers and with cytoplasmic constituents. The Epic System is a high-throughput, label-free detection platform with demonstrated utility for drug discovery in both biochemical and cell-based assay applications.

Speaker: Professor L.K. Kaczmareck

Dr. Kaczmarek has been a Yale faculty member since 1981 and served as Chairman of the Yale Department of Pharmacology from 1989 to 1998. His lab studies the regulation of ion channels, particularly by protein kinase. Dr. Kaczmarek has authored or edited several books, and is co-author of the textbook "The Neuron".

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